Functional measures on PEDI are associated with BSID-3 scales at 2 years, following neonatal surgery.

BACKGROUND: Neonates requiring early surgical intervention for major non-cardiac congenital anomalies are at high risk of adverse neurodevelopmental outcomes. Early recognition of potential neuro-developmental delay is critical to facilitate access to early childhood intervention services and therefore maximise the functional capabilities of these children. AIMS: This study aims to compare Bayley's Scales of Infant and Toddler Development (BSID-3) and the Paediatric Evaluation of Disability Inventory (PEDI) as early screening tools in predicting neuro-developmental disability across multiple domains. In addition, it looks at determining which pre, peri and post-operative risk factors lend themselves to more adverse outcomes. STUDY DESIGN: Retrospective cohort study. SUBJECTS: Neonates requiring surgical intervention at the Royal Children's Hospital from 2012 to 2018 who subsequently underwent neurodevelopmental assessment at 2 years of age. OUTCOME MEASURES: The main outcome was the relationship between performance on the PEDI compared with the BSID-3, in 2-year-olds following neonatal surgery. RESULTS: Parent -reported functional measures across all domains on PEDI strongly related to the more formal measures of cognition, language, and motor development assessed on BSID-3 (p < 0.05). CONCLUSIONS: The questionnaire-based PEDI tool could be considered a reliable replacement to the formal Bayley (BSID-3) scale in low-risk infants and provide a more accessible means of assessment where there are deficiencies in availability of suitably trained clinicians or limited resource centres.

Extubation generates lung volume inhomogeneity in preterm infants.

OBJECTIVE: To evaluate the feasibility of electrical impedance tomography (EIT) to describe the regional tidal ventilation (VT) and change in end-expiratory lung volume (EELV) patterns in preterm infants during the process of extubation from invasive to non-invasive respiratory support. DESIGN: Prospective observational study. SETTING: Single-centre tertiary neonatal intensive care unit. PATIENTS: Preterm infants born <32 weeks' gestation who were being extubated to nasal continuous positive airway pressure as per clinician discretion. INTERVENTIONS: EIT measurements were taken in supine infants during elective extubation from synchronised positive pressure ventilation (SIPPV) before extubation, during and then at 2 and 20 min after commencing nasal continuous positive applied pressure (nCPAP). Extubation and pressure settings were determined by clinicians. MAIN OUTCOME MEASURES: Global and regional ΔEELV and ΔVT, heart rate, respiratory rate and oxygen saturation were measured throughout. RESULTS: Thirty infants of median (range) 2 (1, 21) days were extubated to a median (range) CPAP 7 (6, 8) cm H2O. SpO2/FiO2 ratio was a mean (95% CI) 50 (35, 65) lower 20 min after nCPAP compared with SIPPV. EELV was lower at all points after extubation compared with SIPPV, and EELV loss was primarily in the ventral lung (p=0.04). VT was increased immediately after extubation, especially in the central and ventral regions of the lung, but the application of nCPAP returned VT to pre-extubation patterns. CONCLUSIONS: EIT was able to describe the complex lung conditions occurring during extubation to nCPAP, specifically lung volume loss and greater use of the dorsal lung. EIT may have a role in guiding peri-extubation respiratory support.

Distribution of tidal ventilation during volume-targeted ventilation is variable and influenced by age in the preterm lung.

PURPOSE: Synchronised volume-targeted ventilation (SIPPV + VTV) attempts to reduce lung injury by standardising volume delivery to the preterm lung. The aim of this study is to describe the regional distribution and variability of ventilation within the preterm lung during SIPPV + VTV. METHODS: Twenty-seven stable, supine, preterm infants with <32 weeks gestation receiving SIPPV + VTV were studied. From each infant, the anterior-to-posterior impedance change due to tidal ventilation (∆Z (VT); countless units) was determined during every breath from three, 30-s, electrical impedance tomography recordings. ∆Z (VT) within the anterior, middle and posterior thirds of the chest were compared using area under the curve analysis. The coefficient of variation (CV) of ∆Z (VT) in the anterior and posterior hemithoraces, inflation pressure and, where available, V (T) at airway opening were compared. Infants were sub-grouped by age (≤7 and >7 days), supplemental oxygen requirement and set tidal volume. RESULTS: In all sub-groups, the middle third of the chest accounted for the greatest ∆Z (VT) [p < 0.0001, repeated-measures analysis of variance (ANOVA)]. The middle third of the chest constituted a greater relative ∆Z (VT) in infants aged >7 days compared with ≤7 days (p < 0.0001, repeated-measures ANOVA). Set tidal volume and oxygen requirement did not significantly influence the regional distribution of ∆Z (VT). The mean (standard deviation, SD) CV of ∆Z (VTANT) and ∆Z (VTPOST) were 30.6% (14.0%) and 31.9% (12.7%). ∆Z (VTANT) and ∆Z (VTPOST) expressed greater breath-to-breath variability than the variation in inflation pressure and V (T) at airway opening (p = 0.012 and p < 0.0001, respectively, paired t-tests). CONCLUSION: During SIPPV + VTV the preterm infant exhibits marked breath-to-breath variability in regional ventilation which is influenced by age.

Regional distribution of blood volume within the preterm infant thorax during synchronised mechanical ventilation.

PURPOSE: Perfusion in healthy adults is gravity-dependent. Little is known about lung perfusion in the preterm infant. The aim of this study was to describe the regional distribution of blood volume within the thorax in preterm infants receiving synchronised volume-targeted mechanical ventilation (SIPPV + TTV) and to compare this to regional distribution of tidal ventilation using electrical impedance tomography (EIT). METHODS: Stable supine ventilated preterm infants (<32-week gestation) were studied. Three sets of artefact-free 30-s EIT recordings of the right hemithorax were filtered in the cardiac and respiratory frequency domains to differentiate impedance change due to blood (ΔZ (c)) and gas volume (ΔZ (v)). The distribution of ΔZ (c) and ΔZ (v) in the anterior-to-posterior regions of the right chest were compared. Infants were subdivided by age (≤ 7, >7 days) and oxygen requirement. RESULTS: A total of 5,471 beats were analysed from 26 infants (78 recordings); mean (standard deviation (SD)) gestational age was 26 (2) weeks and mean (SD) postnatal age was 9 (10) days. The median (interquartile range) ΔZ (c) in the anterior half of the hemithorax was 1.41-fold (0.88-2.11) greater than that in the posterior half. The geometric centre of ΔZ (c) was located at 46.7% of the anterior-posterior thoracic distance, compared to a more centrally located ΔZ (v) (49.6%; p < 0.0001). The ΔZ (v)/ΔZ (c) ratio was 1.7 in the anterior third of the chest and 2.2 in the posterior (p < 0.0001). The area under the curve (AUC) analysis showed that ΔZ (c) was more evenly distributed in infants >7 days of age and not influenced by oxygen requirement. CONCLUSIONS: There are gravity dependent differences in the distribution of blood volume and ventilation in the ventilated preterm chest.